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Propargyl alcohol
CASRN 107-19-7
Contents
0468
Propargyl alcohol; CASRN 107-19-7
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Propargyl alcohol
File On-Line 11/01/1990
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) on-line 01/01/1994
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- Propargyl alcohol
CASRN -- 107-19-7
Last Revised -- 01/01/1994
The oral Reference Dose (RfD) is based on the assumption that thresholds exist
for certain toxic effects such as cellular necrosis. It is expressed in units
of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning
perhaps an order of magnitude) of a daily exposure to the human population
(including sensitive subgroups) that is likely to be without an appreciable
risk of deleterious effects during a lifetime. Please refer to the Background
Document for an elaboration of these concepts. RfDs can also be derived for
the noncarcinogenic health effects of substances that are also carcinogens.
Therefore, it is essential to refer to other sources of information concerning
the carcinogenicity of this substance. If the U.S. EPA has evaluated this
substance for potential human carcinogenicity, a summary of that evaluation
will be contained in Section II of this file.
___I.A.1. ORAL RfD SUMMARY
Critical Effect Experimental Doses* UF MF RfD
-------------------- ----------------------- ----- --- ----------
Renal and hepato- NOAEL: 5 mg/kg/day 3000 1 2E-3
toxicity mg/kg/day
LOAEL: 15 mg/kg/day
Rat Oral Subchronic
Study
U.S. EPA, 1987
*Conversion Factors: Actual dose tested
___I.A.2. PRINCIPAL AND SUPPORTING STUDIES (ORAL RfD)
U.S. EPA. 1987. Rat oral subchronic toxicity study with propargyl alcohol.
Study conducted by the Toxicity Research Laboratory for the Office of Solid
Waste, Washington, DC.
Four groups of male and female rats (30/sex/group) were dosed orally with 0,
5, 15, and 50 mg/kg of propargyl alcohol daily for 13 weeks. The first 10
rats of each group were sacrificed on days 28-29 after dosing and the
remaining rats were sacrificed on days 91 or 92 after dosing. Parameters
examined included body and organ weight changes, food consumption, and
hematological and histopathological evaluations. Treatment-related mortality
was reported in the 50-mg/kg dosage group, although the precise cause was not
identified. Hepatocytic megalocytosis with a less prominent proliferation of
the bile ducts and cytoplasmic vacuolation of hepatocytes was observed in all
rats in the 50 mg/kg group dosed for 1 or 3 months, in all 15 mg/kg rats dosed
for 3 months, and in 9/10 males and 5/10 females dosed for 1 month. In the
low-dose group, megalocytosis was seen only in one rat treated for 3 months.
Karyomegaly of renal tubular epithelial cells was reported to occur in a dose-
response fashion in the mid- and high-dose groups, but not in the low-dosage
group. Hematological changes and some enzyme changes characteristic of liver
damage were seen in the mid- and high-dose animals and were considered to be
treatment-related. Treatment-related effects at the 15 mg/kg/day dose level
included increased liver weights in both genders, increased kidney weights in
females, and megalocytosis of the liver after 4 and 13 weeks of dosing; this
dose is considered a LOAEL. The daily oral administration of 5 mg/kg of
propargyl alcohol produced no apparent treatment-related effects and is
considered the NOAEL for this study.
___I.A.3. UNCERTAINTY AND MODIFYING FACTORS (ORAL RfD)
UF -- An uncertainty factor of 3000 was used: 10 for interspecies conversion,
10 for intraspecies sensitivity differences, 10 for subchronic study use for
chronic RfD derivation and 3 for the lack of toxicity data in a second species
and reproductive/developmental studies.
MF -- None
___I.A.4. ADDITIONAL COMMENTS (ORAL RfD)
No other chronic, subchronic, or developmental/reproductive toxicity studies
were found in the literature.
___I.A.5. CONFIDENCE IN THE ORAL RfD
Study -- Medium
Data Base -- Low
RfD -- Low
The critical study identified both a NOAEL and a LOAEL for multiple endpoints
and is considered to be of medium confidence. Confidence in the data base is
low due to the lack of supporting subchronic, chronic, and
reproductive/developmental studies. Low confidence in the RfD follows.
___I.A.6. EPA DOCUMENTATION AND REVIEW OF THE ORAL RfD
Source Document -- This assessment is not presented in any existing U.S. EPA
document.
Other EPA Documentation -- U.S. EPA, 1987
Agency Work Group Review -- 02/21/1990
Verification Date -- 02/21/1990
___I.A.7. EPA CONTACTS (ORAL RfD)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- Propargyl alcohol
CASRN -- 107-19-7
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- Propargyl alcohol
CASRN -- 107-19-7
This substance/agent has not undergone a complete evaluation and determination
under US EPA's IRIS program for evidence of human carcinogenic potential.
_VI. BIBLIOGRAPHY
Substance Name -- Propargyl alcohol
CASRN -- 107-19-7
Last Revised -- 01/01/1994
__VI.A. ORAL RfD REFERENCES
U.S. EPA. 1987. Rat oral subchronic toxicity study with propargyl alcohol.
Study conducted by the Toxicity Research Laboratory for the Office of Solid
Waste, Washington, DC.
__VI.B. INHALATION RfC REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
None
_VII. REVISION HISTORY
Substance Name -- Propargyl alcohol
CASRN -- 107-19-7
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
11/01/1990 I.A. Oral RfD summary on-line
11/01/1990 VI. Bibliography on-line
01/01/1992 IV. Regulatory Action section on-line
07/01/1993 I.A.6. Other EPA Documentation added
01/01/1994 I.A.1. Citation year changed to 1987
01/01/1994 I.A.2. Citation year changed to 1987
01/01/1994 I.A.6. Citation year changed to 1987
01/01/1994 VI.A. Reference year changed to 1987
VIII. SYNONYMS
Substance Name -- Propargyl alcohol
CASRN -- 107-19-7
Last Revised -- 11/01/1990
107-19-7
2-Propyn-1-ol
Ethynylcarbinol
HSDB 6054
METHANOL, ETHYNYL-
NA 1986
NSC 8804
Propargyl alcohol
PROPYNYL ALCOHOL
RCRA WASTE NUMBER P102
1-HYDROXY-2-PROPYNE
1-propyn-3-ol
2-PROPYN-1-OL
2-PROPYNOL
2-PROPYNYL ALCOHOL
3-HYDROXY-1-PROPYNE
3-PROPYNOL
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0468.HTM
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