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1,3-Dichlorobenzene
CASRN 541-73-1
Contents
0447
1,3-Dichlorobenzene; CASRN 541-73-1
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR 1,3-Dichlorobenzene
File On-Line 09/01/1990
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) no data 08/01/1992
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) on-line 09/01/1990
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- 1,3-Dichlorobenzene
CASRN -- 541-73-1
Not available at this time.
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- 1,3-Dichlorobenzene
CASRN -- 541-73-1
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- 1,3-Dichlorobenzene
CASRN -- 541-73-1
Last Revised -- 09/01/1990
Section II provides information on three aspects of the carcinogenic
assessment for the substance in question; the weight-of-evidence judgment of
the likelihood that the substance is a human carcinogen, and quantitative
estimates of risk from oral exposure and from inhalation exposure. The
quantitative risk estimates are presented in three ways. The slope factor is
the result of application of a low-dose extrapolation procedure and is
presented as the risk per (mg/kg)/day. The unit risk is the quantitative
estimate in terms of either risk per ug/L drinking water or risk per ug/cu.m
air breathed. The third form in which risk is presented is a drinking water
or air concentration providing cancer risks of 1 in 10,000, 1 in 100,000 or 1
in 1,000,000. The rationale and methods used to develop the carcinogenicity
information in IRIS are described in The Risk Assessment Guidelines of 1986
(EPA/600/8-87/045) and in the IRIS Background Document. IRIS summaries
developed since the publication of EPA's more recent Proposed Guidelines for
Carcinogen Risk Assessment also utilize those Guidelines where indicated
(Federal Register 61(79):17960-18011, April 23, 1996). Users are referred to
Section I of this IRIS file for information on long-term toxic effects other
than carcinogenicity.
__II.A. EVIDENCE FOR CLASSIFICATION AS TO HUMAN CARCINOGENICITY
___II.A.1. WEIGHT-OF-EVIDENCE CLASSIFICATION
Classification -- D; not classifiable as to human carcinogenicity
Basis -- Based on no human data, no animal data and limited genetic data.
___II.A.2. HUMAN CARCINOGENICITY DATA
None.
___II.A.3. ANIMAL CARCINOGENICITY DATA
None.
___II.A.4. SUPPORTING DATA FOR CARCINOGENICITY
An increase in the number of revertants of an auxotrophic strain of
Aspergillus nidulans occurred when spores were treated with 1,3-
dichlorobenzene (concentration and length of treatment not stated). The
spontaneous reversion frequency of the strain was 3/100,000 and the reversion
frequency of treated spores 11/100,000; this increase was not statistically
significant (Prasad and Pramer, 1968).
__II.B. QUANTITATIVE ESTIMATE OF CARCINOGENIC RISK FROM ORAL EXPOSURE
None.
__II.C. QUANTITATIVE ESTIMATE OF CARCINOGENIC RISK FROM INHALATION EXPOSURE
None.
__II.D. EPA DOCUMENTATION, REVIEW, AND CONTACTS (CARCINOGENICITY ASSESSMENT)
___II.D.1. EPA DOCUMENTATION
Source Document -- U.S. EPA, 1985
The 1985 Health Assessment Document for Chlorinated Benzenes has received
Agency review and approval for publication.
___II.D.2. REVIEW (CARCINOGENICITY ASSESSMENT)
Agency Work Group Review -- 12/06/1989
Verification Date -- 12/06/1989
___II.D.3. U.S. EPA CONTACTS (CARCINOGENICITY ASSESSMENT)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
_VI. BIBLIOGRAPHY
Substance Name -- 1,3-Dichlorobenzene
CASRN -- 541-73-1
Last Revised -- 09/01/1990
__VI.A. ORAL RfD REFERENCES
None
__VI.B. INHALATION RfD REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
Prasad, I. and D. Pramer. 1968. Mutagenic activity of some chloranilines and
chlorobenzenes. Genetics. 60: 212-213. (Abstr.)
U.S. EPA. 1985. Health Assessment Document for Chlorinated Benzenes.
Prepared by the Office of Health and Environmental Assessment, Environmental
Criteria and Assessment Office, Cincinnati, OH, for the Office of Solid Waste
and Emergency Response, Washington, DC.
_VII. REVISION HISTORY
Substance Name -- 1,3-Dichlorobenzene
CASRN -- 541-73-1
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
09/01/1990 II. Carcinogen assesment on-line
09/01/1990 VI. Bibliography on-line
01/01/1992 IV. Regulatory Action section on-line
08/01/1992 I.A. Oral RfD now under review
VIII. SYNONYMS
Substance Name -- 1,3-Dichlorobenzene
CASRN -- 541-73-1
Last Revised -- 09/01/1990
541-73-1
BENZENE, 1,3-DICHLORO-
BENZENE, M-DICHLORO-
1,3-DICHLOROBENZENE
M-DICHLOROBENZENE
M-DICHLOROBENZOL
HSDB 522
M-PHENYLENE DICHLORIDE
NSC 8754
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0447.HTM
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