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Baygon
CASRN 114-26-1
Contents
0210
Baygon; CASRN 114-26-1
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Baygon
File On-Line 09/30/1987
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) on-line 07/01/1992
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- Baygon
CASRN -- 114-26-1
Last Revised -- 07/01/1992
The oral Reference Dose (RfD) is based on the assumption that thresholds exist
for certain toxic effects such as cellular necrosis. It is expressed in units
of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning
perhaps an order of magnitude) of a daily exposure to the human population
(including sensitive subgroups) that is likely to be without an appreciable
risk of deleterious effects during a lifetime. Please refer to the Background
Document for an elaboration of these concepts. RfDs can also be derived for
the noncarcinogenic health effects of substances that are also carcinogens.
Therefore, it is essential to refer to other sources of information concerning
the carcinogenicity of this substance. If the U.S. EPA has evaluated this
substance for potential human carcinogenicity, a summary of that evaluation
will be contained in Section II of this file.
___I.A.1. ORAL RfD SUMMARY
Critical Effect Experimental Doses* UF MF RfD
-------------------- ----------------------- ----- --- ---------
Mild cholinergic NOEL: None 100 1 4E-3
symptoms and RBC mg/kg/day
ChE inhibition LEL: 0.36 mg/kg/day
Single-Dose Human
Study
Vandekar et al., 1971
*Conversion Factors: none
___I.A.2. PRINCIPAL AND SUPPORTING STUDIES (ORAL RfD)
Vandekar, M., R. Plestina and K. Wilhelm. 1971. Toxicity of carbamates for
mammals. Bull. World. Health. Org. 44: 241-249.
An unspecified number of human volunteers received a single oral dose of 0.36
mg/kg baygon. This single dose caused mild cholinergic signs and 43%
inhibition of red blood cell cholinesterase in 10 minutes.
___I.A.3. UNCERTAINTY AND MODIFYING FACTORS (ORAL RfD)
UF -- An uncertainty factor of 100 was used to account for the differences of
sensitivity in the human population and to account for the fact that effects
were observed at 0.36 mg/kg/day.
MF -- None
___I.A.4. ADDITIONAL COMMENTS (ORAL RfD)
Data Considered for Establishing the RfD:
1) Oral Dosages - human: Principal study - see previous description; core
grade supplementary
2) 2-Year Feeding (oncogenic) - rat: Systemic NOEL=200 ppm (10 mg/kg/day);
Systemic LEL=1000 ppm (50 mg/kg/day) (weight depression, increased incidence
of urothelial hyperplasia of the bladder, slight increase in neuropathy); core
grade minimum (Mobay Chemical, 1984a)
3) 12-Month Feeding - dog: NOEL=200 ppm (5 mg/kg/day); LEL=600 ppm (15
mg/kg/day) (increased mean liver weight and N-demethylase activity, increased
plasma cholesterol); ChE NOEL=none; ChE LEL=200 ppm; core grade supplementary
(Mobay Chemical, 1984b)
4) 3-Generation Reproduction - rat: Reproductive NOEL=250 ppm (12.5
mg/kg/day); Reproductive LEL=750 ppm (37.5 mg/kg/day) (decreased pup number);
no core grade (Mobay Chemical, 1968)
5) Teratology - rat: Maternal NOEL=1000 ppm (50 mg/kg/day); Maternal LEL=3000
ppm (150 mg/kg/day) (body weight gain and food consumption decreased);
Fetotoxic NOEL=1000 ppm (50 mg/kg/day); Fetotoxic LEL=3000 ppm (150 mg/kg/day)
(average weight of fetus significantly lower); Teratogenic NOEL=10,000 ppm
(500 mg/kg/day) (HDT); Teratogenic LEL=none; no core grade (Chemagro Corp.,
1971)
6) Teratology - rabbit: Maternal NOEL=10 mg/kg/day (HDT); Maternal LEL=none;
Fetotoxic NOEL=10 mg/kg/day (HDT); Fetotoxic LEL=none; Teratogenic NOEL=10
mg/kg/day (HDT); Teratogenic LEL=none; core grade minimum (Mobay Chemical,
1981a)
Other Data Reviewed:
1) 2-Year Feeding (oncogenic) - mice: Systemic NOEL=700 ppm (105 mg/kg/day);
Systemic LEL=2000 ppm (300 mg/kg/day); core grade minimum (Mobay Chemical,
1981b)
2) 2-Year Feeding (oncogenic) - rat: Systemic NOEL=250 ppm (12.5 mg/kg/day);
Systemic LEL=750 ppm (increased liver weight), ChE not established (because of
lack of method); core grade supplementary for oncogenicity (pathology reported
for only 5 rats/sex/group) (Chemagro Corp., 1976)
3) 2-Year Feeding - dog: NOEL=250 ppm (6.25 mg/kg/day); LEL=750 ppm (18.75
mg/kg/day) (decreased body weight; food consumption; increased liver weight);
ChE NOEL not established because of lack of method; no core grade (Chemagro
Corp., 1968)
Data Gap(s): Short-term dog study measuring ChE depression
___I.A.5. CONFIDENCE IN THE ORAL RfD
Study -- Low
Data Base -- Medium
RfD -- Medium
The critical study appears to be of poor quality and is given a low confidence
rating. Additional studies are of adequate quality and, therefore, the data
base is given a medium confidence rating. Medium confidence in the RfD
follows.
___I.A.6. EPA DOCUMENTATION AND REVIEW OF THE ORAL RfD
Pesticide Registration Files
Agency Work Group Review -- 12/09/1986, 02/18/1987
Verification Date -- 02/18/1987
___I.A.7. EPA CONTACTS (ORAL RfD)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- Baygon
CASRN -- 114-26-1
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- Baygon
CASRN -- 114-26-1
Not available at this time.
_VI. BIBLIOGRAPHY
Substance Name -- Baygon
CASRN -- 114-26-1
Last Revised -- 10/01/1990
__VI.A. ORAL RfD REFERENCES
Chemagro Corporation. 1968. MRID No. 00035423. Available from EPA. Write
to FOI, EPA, Washington DC 20460.
Chemagro Corporation. 1971. MRID No. 00045094. Available from EPA. Write
to FOI, EPA, Washington DC 20460.
Chemagro Corporation. 1976. MRID No. 00035425, 00070673. Available from
EPA. Write to FOI, EPA, Washington DC 20460.
Mobay Chemical Company. 1968. MRID No. 00052277, 00055142. Available from
EPA. Write to FOI, EPA, Washington DC 20460.
Mobay Chemical Company. 1981a. MRID No. 00100547. Available from EPA. Write
to FOI, EPA, Washington DC 20460.
Mobay Chemical Company. 1981b. MRID No. 00100546, 00138815. Available from
EPA. Write to FOI, EPA, Washington DC 20460.
Mobay Chemical Company. 1984a. MRID No. 0014275. Available from EPA. Write
to FOI, EPA, Washington DC 20460.
Mobay Chemical Company. 1984b. MRID No. 00149040. Available from EPA.
Write to FOI, EPA, Washington DC 20460.
Vandekar, M., R. Plestina and K. Wilhelm. 1971. Toxicity of carbamates for
mammals. Bull. World. Health. Org. 44: 241-249.
__VI.B. INHALATION RfD REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
None
_VII. REVISION HISTORY
Substance Name -- Baygon
CASRN -- 114-26-1
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
03/31/1987 I.A.6. Documentation corrected
03/31/1987 IV.A. Pesticide AI data added
11/01/1989 VI. Bibliography on-line
10/01/1990 III.A. Health Advisory on-line
10/01/1990 VI.D. Health Advisory references added
01/01/1992 IV. Regulatory action updated
07/01/1992 I.A.4. Study 5) citation corrected
VIII. SYNONYMS
Substance Name -- Baygon
CASRN -- 114-26-1
Last Revised -- 09/30/1987
114-26-1
APROCARB
ARPROCARB
BAY 39007
BAY 9010
BAYER 39007
Baygon
BIFEX
BLATTANEX
BOYGON
BRYGOU
CARBAMIC ACID, METHYL-, 2-(1-METHYLETHOXY)PHENYL ESTER
CHEMAGRO 9010
ENT 25,671
HYDROXY-N,N-DIMETHYLCROTONAMIDE
o-IMPC
INVISI-GARD
ISOCARB
2-ISOPROPOXYPHENYL METHYLCARBAMATE
o-ISOPROPOXYPHENYL METHYLCARBAMATE
2-ISOPROPOXYPHENYL-N-METHYLCARBAMAT
2-ISOPROPOXYPHENYL N-METHYLCARBAMATE
o-ISOPROPOXYPHENYL N-METHYLCARBAMATE
2-(1-METHYLETHOXY)PHENOL METHYLCARBAMATE
N-METHYL-2-ISOPROPOXYPHENYLCARBAMATE
OMS-33
PHC
PHENOL, o-ISOPROPOXY-, METHYLCARBAMATE
PROPOKSURU
PROPOTOX M
PROPOXUR
PROPOXURE
PROPYON
SENDRAN
SUNCIDE
TUGON FLIEGENKUGEL
UNDEN
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0210.HTM
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