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delta-Hexachlorocyclohexane (delta-HCH)
CASRN 319-86-8
Contents
0163
delta-Hexachlorocyclohexane (delta-HCH); CASRN 319-86-8
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR delta-HCH
File On-Line 03/31/1987
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) no data
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) on-line 07/01/1993
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- delta-Hexachlorocyclohexane (delta-HCH)
CASRN -- 319-86-8
Not available at this time.
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- delta-Hexachlorocyclohexane (delta-HCH)
CASRN -- 319-86-8
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- delta-Hexachlorocyclohexane (delta-HCH)
CASRN -- 319-86-8
Last Revised -- 07/01/1993
Section II provides information on three aspects of the carcinogenic
assessment for the substance in question; the weight-of-evidence judgment of
the likelihood that the substance is a human carcinogen, and quantitative
estimates of risk from oral exposure and from inhalation exposure. The
quantitative risk estimates are presented in three ways. The slope factor is
the result of application of a low-dose extrapolation procedure and is
presented as the risk per (mg/kg)/day. The unit risk is the quantitative
estimate in terms of either risk per ug/L drinking water or risk per ug/cu.m
air breathed. The third form in which risk is presented is a drinking water
or air concentration providing cancer risks of 1 in 10,000, 1 in 100,000 or 1
in 1,000,000. The rationale and methods used to develop the carcinogenicity
information in IRIS are described in The Risk Assessment Guidelines of 1986
(EPA/600/8-87/045) and in the IRIS Background Document. IRIS summaries
developed since the publication of EPA's more recent Proposed Guidelines for
Carcinogen Risk Assessment also utilize those Guidelines where indicated
(Federal Register 61(79):17960-18011, April 23, 1996). Users are referred to
Section I of this IRIS file for information on long-term toxic effects other
than carcinogenicity.
__II.A. EVIDENCE FOR CLASSIFICATION AS TO HUMAN CARCINOGENICITY
___II.A.1. WEIGHT-OF-EVIDENCE CLASSIFICATION
Classification -- D; not classifiable as to human carcinogenicity
___II.A.2. HUMAN CARCINOGENICITY DATA
None.
___II.A.3. ANIMAL CARCINOGENICITY DATA
No neoplastic or nonneoplastic effects were noted in livers of male dd
mice or Wistar rats given dietary delta-HCH at concentrations ranging from
100-1000 ppm (Ito et al., 1975, 1973a,b; Nagasaki et al., 1972). Both of
these studies utilized small numbers of animals treated for 24 weeks and
examined only livers. Goto et al. (1972) observed increased incidence of
benign and malignant hepatomas in ICR-JCL mice fed for 26 weeks with a 600 ppm
mixture of delta- and epsilon-HCH. Individual isomers were not tested.
___II.A.4. SUPPORTING DATA FOR CARCINOGENICITY
delta-HCH is structurally related to carcinogenic HCH.
__II.B. QUANTITATIVE ESTIMATE OF CARCINOGENIC RISK FROM ORAL EXPOSURE
Not available.
__II.C. QUANTITATIVE ESTIMATE OF CARCINOGENIC RISK FROM INHALATION EXPOSURE
Not available.
__II.D. EPA DOCUMENTATION, REVIEW, AND CONTACTS (CARCINOGENICITY ASSESSMENT)
___II.D.1. EPA DOCUMENTATION
Source Document -- U.S. EPA, 1986
The 1986 Health and Environmental Effects Profile has received an Agency
review.
___II.D.2. REVIEW (CARCINOGENICITY ASSESSMENT)
Agency Work Group Review -- 12/17/1986
Verification Date -- 12/17/1986
___II.D.3. U.S. EPA CONTACTS (CARCINOGENICITY ASSESSMENT)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
_VI. BIBLIOGRAPHY
Substance Name -- delta-Hexachlorocyclohexane (delta-HCH)
CASRN -- 319-86-8
Last Revised -- 08/01/1991
__VI.A. ORAL RfD REFERENCES
None
__VI.B. INHALATION RfD REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
Goto, M., M. Hattori, T. Miyagawa and M. Enomoto. 1972. Contribution on
ecological chemistry. II. Formation of hepatoma in mice after ingestion of
HCH isomers in high doses. Chemosphere. 1(6): 279-282.
Ito, N., H. Nagasaki, H. Aoe, et al. 1975. Brief communication: Development
of hepatocellular carcinomas in rats treated with benzene hexachloride. J.
Natl. Cancer Inst. 54(3): 801-805.
Ito, N., H. Nagasaki, M. Arai, S. Sugihara and S. Makiua. 1973a. Histologic
and ultrastructural studies on the hepatocarcinogenicity of benzene
hexachloride. J. Natl. Cancer Inst. 51(3): 817-826.
Ito, N., H. Nagasaki, M. Arai, S. Makiura, S. Sugihara and K. Hirao. 1973b.
Histopathologic studies on liver tumorigenesis induced in mice by technical
polychlorinated biphenyls and its promoting effect on liver tumors induced by
benzene hexachloride. J. Natl. Cancer Inst. 51(5): 1637-1646.
Nagasaki, H., S. Tomii, T. Mega, M. Marugami and N. Ito. 1972. Proc. 2nd Int.
Symp. Princess Takamatsu Cancer Research Fund. In: Topics in Chemical
Carcinogenesis, W. Nakahara, et al., Ed. XIX+530P Illus. University Park
Press, Baltimore, MD, USA; Tokyo, Japan. p. 343-353.
U.S. EPA. 1986. Health and Environmental Effects Profile for
Hexachlorocyclohexanes. Prepared by the Office of Health and Environmental
Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for
the Office of Solid Waste and Emergency Response, Washington, DC.
_VII. REVISION HISTORY
Substance Name -- delta-Hexachlorocyclohexane (delta-HCH)
CASRN -- 319-86-8
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
08/01/1991 IV.F.1. EPA contact changed
08/01/1991 VI. Bibliography on-line
01/01/1992 IV. Regulatory actions updated
07/01/1993 II.D.3. Secondary contact's phone number changed
VIII. SYNONYMS
Substance Name -- delta-Hexachlorocyclohexane (delta-HCH)
CASRN -- 319-86-8
Last Revised -- 03/31/1987
319-86-8
delta-BENZENEHEXACHLORIDE
delta-BHC
CYCLOHEXANE, delta-1,2,3,4,5,6-HEXACHLORO-
CYCLOHEXANE, 1,2,3,4,5,6-HEXACHLORO-, delta-isomer
ENT 9,234
delta-HCH
1-alpha,2-alpha,3-alpha,4-beta,5-alpha,6-beta-HEXACHLOROCYCLOHEXANE
Hexachlorocyclohexane, delta-
delta-1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE
delta-(aeeeee)-1,2,3,4,5,6-HEXACHLOROCYCLOHEXANE
delta-LINDANE
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0163.HTM
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