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Acifluorfen, sodium
CASRN 62476-59-9
Contents
0192
Acifluorfen, sodium; CASRN 62476-59-9
Health assessment information on a chemical substance is included in IRIS only
after a comprehensive review of chronic toxicity data by U.S. EPA health
scientists from several Program Offices and the Office of Research and
Development. The summaries presented in Sections I and II represent a
consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Acifluorfen, sodium
File On-Line 03/31/1987
Category (section) Status Last Revised
----------------------------------------- -------- ------------
Oral RfD Assessment (I.A.) on-line 12/01/1988
Inhalation RfC Assessment (I.B.) no data
Carcinogenicity Assessment (II.) no data 11/01/1993
_I. CHRONIC HEALTH HAZARD ASSESSMENTS FOR NONCARCINOGENIC EFFECTS
__I.A. REFERENCE DOSE FOR CHRONIC ORAL EXPOSURE (RfD)
Substance Name -- Acifluorfen, sodium
CASRN -- 62476-59-9
Primary Synonym -- Tackle
Last Revised -- 12/01/1988
The oral Reference Dose (RfD) is based on the assumption that thresholds exist
for certain toxic effects such as cellular necrosis. It is expressed in units
of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning
perhaps an order of magnitude) of a daily exposure to the human population
(including sensitive subgroups) that is likely to be without an appreciable
risk of deleterious effects during a lifetime. Please refer to the Background
Document for an elaboration of these concepts. RfDs can also be derived for
the noncarcinogenic health effects of substances that are also carcinogens.
Therefore, it is essential to refer to other sources of information concerning
the carcinogenicity of this substance. If the U.S. EPA has evaluated this
substance for potential human carcinogenicity, a summary of that evaluation
will be contained in Section II of this file.
___I.A.1. ORAL RfD SUMMARY
Critical Effect Experimental Doses* UF MF RfD
-------------------- ----------------------- ----- --- ---------
Mortality and kidney NOEL: 25 ppm (diet) 100 1 1.3E-2
lesions (1.25 mg/kg/day) mg/kg/day
2-Generation LEL: 500 ppm (diet)
Reproduction Rat (25 mg/kg/day)
Study
Rhone-Poulenc, Inc.,
1986
*Conversion Factors: 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
___I.A.2. PRINCIPAL AND SUPPORTING STUDIES (ORAL RfD)
Rhone-Poulenc, Inc. 1986. MRID No. 00147978, 00155548. Available from EPA.
Write to FOI, EPA, Washington, DC 20460.
The test material, technical grade tackle, was prepared weekly on a weight-
per-weight basis to yield tackle concentrations of 0, 25, 500 and 2500 ppm.
Diets were administered ad libitum to groups of 35 P1 rats/sex beginning at 47
days of age and continuing until sacrifice, and to groups of 40 F1 rats from
weaning until sacrifice. The LEL and NOEL for parental toxicity of tackle was
assessed at 500 ppm and 25 ppm, respectively, based on compound-related
mortalities and increased incidence of kidney lesions at the 500 and 2500 ppm
doses, and reduced body weights at the 2500-ppm dose. The LEL and NOEL for
offspring toxicity were assessed at 500 ppm and 25 ppm, respectively, based on
decreased viability and increased incidence of kidney lesions at the 500 and
2500 ppm doses, and reduced body weight at the 2500-ppm dose.
___I.A.3. UNCERTAINTY AND MODIFYING FACTORS (ORAL RfD)
UF -- An uncertainty factor of 100 was used to account for the inter- and
intraspecies differences.
MF -- None
___I.A.4. ADDITIONAL COMMENTS (ORAL RfD)
None
Data Considered for Establishing the RfD:
1) 2-Generation Reproduction - rat: Principal study - see previous
description; core grade minimum
2) 2-Year Feeding - dog: NOEL=300 ppm (7.5 mg/kg/day); LEL=4500 ppm (112.5
mg/kg/day) (increased leukocyte and platelet counts in males; decreased mean
calcium, cholesterol and creatinine values in females); core grade
supplementary (Rhone-Poulenc, Inc., 1983a)
3) 2-Year Feeding (oncogenic) - rat: NOEL=500 ppm (25 mg/kg/day); LEL=2500
ppm (elevated BUN and creatinine values in males and females; nephritis,
pyelonephritis, and glomerulonephritis in males); core grade supplementary
(Rhone-Poulenc, Inc., 1983b)
4) Teratology - rabbit: Maternal NOEL=36 mg/kg/day (HDT); Fetotoxic NOEL=36
mg/kg/day (HDT); Teratogenic NOEL=36 mg/kg/day (HDT); core grade minimum
(Rhone-Poulenc, Inc., 1980)
5) Teratology - rat: Maternal NOEL=90 mg/kg/day; Maternal LEL=180 mg/kg/day
(HDT) (lower body weight); Fetotoxic NOEL=20 mg/kg/day (LDT); Fetotoxic LEL=90
mg/kg/day (reduced fetal weight); Teratogenic NOEL=180 mg/kg/day (HDT); core
grade guideline (Rhone-Poulenc, Inc., 1981)
Data Gap(s): Chronic Dog Feeding Study
___I.A.5. CONFIDENCE IN THE ORAL RfD
Study -- Medium
Data Base -- Medium
RfD -- Medium
The principal study is of fair quality and is given a medium confidence
rating. Several supporting studies exist, but the data base on chronic
toxicity is incomplete; thus, the data base is given a medium confidence
rating. Medium confidence in the RfD follows.
___I.A.6. EPA DOCUMENTATION AND REVIEW OF THE ORAL RfD
Pesticide Registration Files
Agency Work Group Review -- 09/29/1986, 12/16/1986
Verification Date -- 12/16/1986
___I.A.7. EPA CONTACTS (ORAL RfD)
Please contact the Risk Information Hotline for all questions concerning this
assessment or IRIS, in general, at (513)569-7254 (phone), (513)569-7159 (FAX)
or RIH.IRIS@EPAMAIL.EPA.GOV (internet address).
__I.B. REFERENCE CONCENTRATION FOR CHRONIC INHALATION EXPOSURE (RfC)
Substance Name -- Acifluorfen, sodium
CASRN -- 62476-59-9
Primary Synonym -- Tackle
Not available at this time.
_II. CARCINOGENICITY ASSESSMENT FOR LIFETIME EXPOSURE
Substance Name -- Acifluorfen, sodium
CASRN -- 62476-59-9
Primary Synonym -- Tackle
Not available at this time.
_VI. BIBLIOGRAPHY
Substance Name -- Acifluorfen, sodium
CASRN -- 62476-59-9
Primary Synonym -- Tackle
Last Revised -- 10/01/1990
__VI.A. ORAL RfD REFERENCES
Rhone-Poulenc, Inc. 1980. MRID No. 00122744. Available from EPA. Write to
FOI, EPA, Washington, D.C. 20460.
Rhone-Poulenc, Inc. 1981. MRID No. 00122743. Available from EPA. Write to
FOI, EPA, Washington, D.C. 20460.
Rhone-Poulenc, Inc. 1983a. MRID No. 00122735, 00131162. Available from EPA.
Write to FOI, EPA, Washington, D.C. 20460.
Rhone-Poulenc, Inc. 1983b. MRID No. 00128353. Available from EPA. Write to
FOI, EPA, Washington, D.C. 20460.
Rhone-Poulenc, Inc. 1986. MRID No. 00147978, 00155548. Available from EPA.
Write to FOI, EPA, Washington, D.C. 20460.
__VI.B. INHALATION RfD REFERENCES
None
__VI.C. CARCINOGENICITY ASSESSMENT REFERENCES
None
_VII. REVISION HISTORY
Substance Name -- Acifluorfen, sodium
CASRN -- 62476-59-9
Primary Synonym -- Tackle
-------- -------- --------------------------------------------------------
Date Section Description
-------- -------- --------------------------------------------------------
12/01/1988 I.A.2. Text revised
11/01/1989 VI. Bibliography on-line
10/01/1990 III.A. Health Advisory on-line
10/01/1990 VI.D. Health Advisory references added
11/01/1993 II. Work group review date added
VIII. SYNONYMS
Substance Name -- Acifluorfen, sodium
CASRN -- 62476-59-9
Primary Synonym -- Tackle
Last Revised -- 03/31/1987
62476-59-9
ACIFLUORFEN
ACIFLUORFEN SODIUM
BENZOIC ACID, 5-(2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY)-2-NITRO-, SODIUM SALT
BLAZER
BLAZER 2S
5-(2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY)-2-NITROBENZOIC ACID SODIUM SALT
MC 10978
RH 6201
SCIFLUORFEN
Sodium acifluorfen
SODIUM 5-(2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY)-2-NITROBENZOATE
SODIUM SALT of ACIFLUORFEN
Tackle
TACKLE 2AS
Last updated: 5 May 1998
URL: http://www.epa.gov/iris/SUBST/0192.HTM
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